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The current dilemma with sepsis diagnosis

„Sepsis is defined as life-threatening
organ dysfunction
caused by a
dysregulated host response
to
infection.“

Infection

Diagnosis of infection:


• Too slow
Detects bacteria after
24h-48h (blood culture)

→ Useless for initial treatment decision


• Not reliable:
30-60% of septic patients do not have bacteria in the blood

→ Limited utility to diagnose a sepsis

Immune
response

Diagnosis of Immune response:


• Too unspecific
Similar symptoms in other diseases (heart failure, trauma)


• To unspecific, too slow:
Current markers are upregulated in sterile inflammation without infection

Time to result: at least 6h


→ Limited utility to diagnose a sepsis

Organ

dysfunction

Diagnosis of organ dysfunction:


• Too unspecific
Detects the condition of a patient that can have different reasons

→ Limited utility to diagnose a sepsis

→ prognosis rather than diagnosis

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causes
causes

Sepsis -

each minute counts

Accelerated diagnosis would save lives and billions for healthcare systems
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1h
delay in
diagnosis

+ 8% of sepsis patients
develop septic shock
+ 2-7,5% increased lethality

Delay in diagnosis causes:
- Prolonged hospital stay and time in
intensive care unit (estimated 4 days)
- Prolonged therapy

Standard Recommendation:

1-hour sepsis bundle
 

Treatment within 1 hour after recognition of first signs of sepsis:
 

• Broad spectrum antibiotics
• Cristalloid fluid infusion therapy

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